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2006 Archive
BioTech
Jan 1 - March 27
Mar 27 - April 11
April 12- May 15
May 16 - June 16
June 16-Sept 11
Sept 12 - Oct 23
BIOTECHNOLOGY
Biotech Starts Out on Right Foot in January

SAN FRANCISCO -- While 2006 was one that many of the larger biotech companies would prefer to forget the New Year has started out on a positive note for these bell-weather companies. The Burrill Biotech Select Index, which slipped almost 14% in value by the close of 2006, recovered in January finishing up 4.5% by month end outperforming the NASDAQ, which posted a January gain of 2%, and the Dow just short of that at 1.3%. Although finishing a hair short of its record high, the Dow was bolstered on the final trading day of January by the Federal Reserve holding interest rates steady and citing a pickup in economic growth but no significant shift in monetary policy for now.

"There were some very impressive gains among biotech's elite companies during January, which helped biotech outperform the general markets during January," said G. Steven Burrill, CEO of Burrill & Company a San Francisco based global leader in life sciences with principal activities in Venture Capital, Merchant Banking and Media. "With the Feds holding firm on interest rates, it bodes well for a steady improvement in the fortunes of biotech companies during the year. We saw all Burrill indices performing well this month, something we haven't seen for several months," added Burrill.

"Also helping the cause of was the release of good clinical data by a number of companies at JP Morgan's 25th Annual Healthcare Conference. The 25th anniversary event, held in San Francisco mid-month, continues to set attendance records," noted Burrill. "The four day event featured presentations from over 300 companies."

A case in point was Incyte Corp., whose shares closed up 27% following the release of positive preliminary results from a Phase IIa placebo-controlled trial designed to evaluate the anti-viral effects and safety of INCB9471, the company's lead CCR5 antagonist that is being developed as a once-a-day oral treatment for patients with human immunodeficiency virus (HIV) infections.

"But the buzz around the meeting room hallways was not so much on trial data but the specter of increasing mergers and acquisitions," continued Burrill. "The sector is ripe for significant M&A activity, as big pharma looks to strengthen weak pipelines and replace blockbuster drugs that are coming off patent. There is general industry consensus that biotech firms with drugs on the market or near to market will become prime targets."

A related issue also fuelling M&A revolves around product innovation. Last year was the second in a row that 18 NMEs were approved by the FDA -- a number that is surprising low given the over $50 billion the US industry spends on research and development. During the past eight years, the high point for novel drug approvals was 35 in 1999 and the low was 17 in 2002, according to FDA data.

"This further emphasizes why big pharma will be looking to access biotech's rich innovation," noted Burrill. "We are coming off a year that also saw a record amount of dollars that the biotech industry raised through partnership deals. This is a trend we expect to continue in 2007."

Pfizer could be at the head of this partnering and acquisitions trend following its announcement to pare $2 billion in costs by cutting its workforce by 10,000 and closing research and manufacturing facilities. It has been estimated that Pfizer is faced with the loss of 41% of its revenue to generic competitors between 2010 and 2012 putting pressure on the company to develop new medicines to replace this lost revenue.

It was not only healthcare biotech that grabbed the headlines in January. President Bush, in his State of the Union address, gave an addition boost to stimulate large-scale production of biofuels from cellulosic biomass. Thanks to recent advances in industrial biotechnology, the US is on target to achieve the goal of producing 35 billion gallons of renewable fuel by 2017 the President said.

Perhaps the only negative note to the month was in the stem cell arena. The Nancy Pelosi-led House of Representatives passed a bill promoting embryonic stem cell research but came up short of the two-thirds margin required to overturn a presidential veto. Shares of stem cell companies were adversely affected with companies such as Geron sliding 7% by the close of January.

It was a quiet month for biotech IPOs in January with only one getting out of the gate. Oculus Innovative Sciences, a developer and manufacturer of products designed to prevent infection in wounds, priced three million shares at $8, the low end of its pricing range. In the five trading days since its debut, the company's share value had dropped approximately 4%.

"Biotech has started out on the right foot following a positive month and we will look for this momentum to build in the first quarter of 2007," Burrill concluded.

Consumers face trade-offs in choosing organic or conventional foods

Both organic and conventionally produced foods present consumers with trade-offs in terms of food safety and nutritional content, according to a food toxicologist at the University of California, Davis.

"While there is a growing body of research demonstrating the qualitative differences between organic and conventional foods, it is premature to conclude that either system of food production is superior to the other," says Carl Winter, director of UC Davis' FoodSafe Program. Winter's review of conventional and organic foods was published in the December issue of the Journal of Food Science.

The popularity of organic foods has been growing rapidly in the past two decades, with consumer sales of organic foods increasing by nearly 20 percent annually since 1990, reaching $13.8 billion in 2005, Winter notes.

Surveys indicate that many consumers think organically produced foods are more nutritious and healthful. One survey found that consumers also are choosing organic foods to avoid pesticide residues and genetically modified foods.

Winter's review notes that while organic fruits and vegetables have fewer pesticide residues, they do not necessarily carry less health risk. Research has shown that in some cases organic foods have higher levels of naturally occurring chemical compounds -- including both health-promoting antioxidants and naturally occurring toxins that might be of concern for human health.

In the area of microbial food safety, Winter points out that animal manure fertilizer - used frequently in organic farming and, to a lesser extent, in conventional farming - can pose an increased threat of microbiological contamination. He notes, however, that certified organic production standards provide specific requirements for composting animal manure aimed at preventing microbial contamination, while there are no such standards for conventional food production.

One comprehensive study indicated that certified organic fruits and vegetables did not pose a higher microbiological risk than conventionally produced food crops.

The review notes that there have been mixed findings in the area of microbial safety and animal-based foods. The review does report that the prohibition of antibiotic use in organic animal production seems to result in a lower incidence of resistance to antimicrobial drugs among organically raised animals than among animals raised conventionally.

This peer-reviewed paper was prepared as a Scientific Status Summary by the Institute of Food Technologists.

Copyright © The Regents of the University of California, Davis campus, 2005-06

AU endorses biotechnology plan, but not science fund
By Kennedy Abwao

ADDIS ABABA - Heads of state at the African Union (AU) summit have endorsed a 20-year biotechnology action plan, but failed to reach agreement on an African science and innovation fund.

At the close of the summit in Abbis Ababa, Ethiopia yesterday (30 January), African leaders endorsed almost all proposals in the AU executive council's science report, which was agreed by foreign ministers on Saturday (27 January).

These include designating 2007 Africa's year for innovations (see 2007 to be Africa's 'scientific innovations year') and the creation of a Pan-African intellectual property organisation to protect indegenous innovations.

The biotechnology strategy calls for cooperation among African nations in specific regions to bolster research in different fields of research according to regional strength.

Eastern and northern Africa will work towards improving malaria control measures and managing HIV/AIDS, drawing on expertise from southern Africa nations.

North Africa will advise other regions on drug manufacture, whilst eastern Africa will share its knowledge of livestock research technology. West Africa has expertise in agricultural biotechnology and central Africa in biodiversity.

Countries will be grouped under regional economic bodies to implement goals outlined in the strategy, and will report to the AU on their progress.

Regarding funding, the heads of state decided that further studies were needed on the proposed African Science and Innovation Fund (ASIF).

The fund was originally proposed as an African Science and Innovation Facility, but the leaders disagreed on whether it was prudent to create another institution, which would guzzle more funds and increase operational costs.

They agreed on a fund that would piggyback onto a wider plan to finance the Consolidated Plan of Action (see Support urged for US$160m plan for African science) managed by an existing organisation.

African scientists familiar with the closed-door discussions said an expert panel had been asked to study the proposed institutional framework of ASIF and report to a ministerial meeting to be held in Kenya sometime later this year.

John Mugabe, advisor on science and technology to the New Partnership for Africa's Development, had said earlier that the African Development Bank would likely run ASIF with financial contributions from AU member states.

There was also a proposal to set up an AU-appointed authority to oversee ASIF operations. In their executive council report, African foreign ministers recommended that a legal framework be developed to establish ASIF as an intergovernmental authority, tasked with the promotion of science and technology.
Copyright SciDev.Net

Biotechnology Use and Development Survey for 2005

The number of innovative biotechnology firms grew to 532 in 2005 from 490 in 2003, an increase of 9%, according to new preliminary data from the Biotechnology Use and Development Survey. This was lower than the 31% increase between 2001 and 2003 (from 375 to 490 firms). Between 1997 and 2005, when there were 282 firms, the compound annual growth rate was 8%.

An innovative biotechnology firm is a firm that uses biotechnology for the purpose of developing new products or processes.

Combined, these 532 companies generated revenues of $4.2 billion in 2005, up 9% from 2003. Their spending on research and development (R&D) also increased 15% to $1.7 billion.

Large biotech companies, those with at least 150 employees, represented only 10% of the 532 biotech firms in 2005, but accounted for 68% of biotech revenues. Three-quarters of all companies were small firms, that is, they had fewer than 50 employees.

By contrast, biotechnology related R&D was more equally distributed between the three sizes of firms.

More than 75% of the innovative biotechnology firms were in three provinces: Quebec, Ontario and British Columbia. These provinces continue to comprise the bulk of Canadian biotechnology activity, accounting for more than 90% of biotechnology revenues in 2005.

Ontario firms led the way in biotechnology revenues, R&D expenditures and employment, whereas those in Quebec accounted for the largest share of biotechnology firms.

Biotechnology related to human health remained the most significant biotechnology sector in terms of number of firms, employment, R&D and revenues.

The number of employees with biotechnology responsibilities increased to over 13,400 from about 11,900 in 2003.

Biotechnology key indicators

2005

  Innovative biotechnology companies Employees with biotechnology-related activities Biotechnology revenues Biotechnology R&D expenditures
  number $ millions $ millions
Canada 532 13,433 4,191 1,703
Province        
Atlantic 25 132 33 10
Quebec 181 4,555 449 559
Ontario 144 5,203 2,769 649
Manitoba 19 491 164 84
Saskatchewan 18 167 53E 14
Alberta 51 944 137 102
British Columbia 93 1,942 586 285
Sector        
Human health 303 10,791 2,955 1,486
Agriculture and food processing 130 1,566 1,075 157
Environment 54 654 121 34
Other 45 422 41 27
Size        
Small (0 to 49 employees) 399 4,466 402 576
Medium (50 to 149 employees) 83 3,613 961 492
Large (150 employees and over) 51 5,354 2,829 635
Euse with caution

Asia to drive growth of GMO crops in next decade
By Niu Shuping

BEIJING - Asia is set to become the driving force behind biotech crops in the next decade, despite hesitance by China to commercialize GMO rice, a Chinese scientist and an international body said on Monday January 29, 2007.

In 2006, the first year of the second decade of biotech crops, India took over China as the world's top grower of genetically modified (GMO) cotton, the pro-biotech International Service for the Acquisition of Agri-biotech Applications (ISAAA).

"The second decade will likely feature strong growth in Asia led by China, India and new countries like Pakistan and Vietnam," it said in a report. "The first decade (1996-2005) was the decade of the Americans."

ISAAA said India, which planted Bt cotton for the first time in 2002, had tripled acreage for insect-resistant Bt cotton in 2006 to 3.8 million hectares, surpassing 3.5 million hectares in China.

Jikun Huang, a scientist with the Chinese Academy of Sciences, attributed China's fall to a decreased cotton acreage. Beijing has encouraged farmers to grow more grains due to the country's food security concerns in the past few years.

But Huang said favorable weather helped China boost its 2006 cotton output by 17.8 percent to 6.73 million tonnes. More than 60 percent of Chinese grown cotton was Bt cotton.

"The biotechnology has helped farmers reduce cost and raise production on limited land," said Huang, a Chinese scientist known for promoting biotechnology.

Bt cotton increased income of some 6.8 million farmers as it cut pesticide use by 60 percent, while raising yields by 10 percent compared with conventional varieties, said Huang.

GMO rice, rapeseed

But Huang said Beijing was still against commercialization of GMO rice, a staple food for many of its 1.3 billion people.

"We still hope GMO rice could also be approved for production in the next two to three years," said Huang, adding Beijing was reluctant to give go-ahead because of social and political reasons. He did not elaborate.

Though Beijing looked close to approving GMO rice in early 2005, it has put the brakes on the move following reports that transgenic rice was traded illegally in China.

As Beijing was eager to develop biofuel to reduce its reliance on imported oil, Huang said rapeseed could be the next farm product approved by Beijing for commercial production after it had approved the production of GMO papaya in 2006.

China also plans to raise its budget for biotechnology after spending about 2 billion yuan a year, which mainly goes to the research of GMO rice, said Huang.

ISAAA said it expected the global biotech area to nearly double to 200 million hectares by 2015 from 102 million hectares in 2006 after a 60-fold increase between 1996 and 2006.

© Reuters 2007

UW optometry prof wins U.S. top educator award

WATERLOO - A leading researcher at the University of Waterloo's school of optometry was recognized January 25, 2007, as a top educator by a United States organization, which advances optometric practice by fostering research and disseminating knowledge in vision science.

Lyndon Jones, an associate professor of optometry at UW, has received the 2006 Michael G. Harris Family Award for Excellence in Optometric Education. It was presented last December by the American Optometric Foundation, affiliated with the American Academy of Optometry.

"This is an important award as it recognizes high standards in teaching and scholarship that enhances optometric education," says Thomas Freddo, director of UW's school of optometry. "The award is given to an optometric educator who has shown excellence in the education of optometry students and the advancement of optometric education."

A winner of a UW distinguished teacher award in 2005, Jones has been teaching optometry undergraduates and graduate students since arriving on campus in October 1998. Students have said he "is able to make the most complicated of subjects both interesting and simple" and that his lectures are "interesting, relevant and well-presented."

Jones connects the background theory with clinical practices through his mastery of PowerPoint. He uses relevant diagrams, videos and up-to-date information so students can see real-world applications of theory.

As well, Jones integrates his own research and past experiences into his lectures. He is known as a teacher who encourages classroom discussion. Outside of the classroom, students find him to be approachable and always willing to help.

Jones also strives to help improve optometry education in general.

He was involved in the establishment of Optometric Educators Ltd. in Britain, a company devoted to motivating continuing education in optometry. He gives international lectures to optometrists about improvements in optometric education and the latest developments in optometry, particularly contact lenses and eye disease.

He is in much demand around the world and has given more than 300 invited lectures in over 25 countries. This year, he has invitations to lecture in Singapore, Australia, New Zealand, South Africa, the U.S. and several countries in Europe.

Jones is also the associate director of UW's Centre for Contact Lens Research, which performs clinical research on the ocular response to contact lenses and other forms of vision correction.

He is an expert on bio-compatibility -- the interaction between contact lens materials and eye tissue. His research interests includes the assessment of contact lens deposits, wettability (the degree to which liquids will spread evenly across a surface), friction and the interaction of contact lens materials with the ocular environment.

GM technology develops in the developing world
By Gunjan Sinha

About 100 km north of Durban, South Africa, in a greenhouse chamber no larger than a walk-in closet, Frederik Kloppers clips a slender vial to a baby maize plant's new leaf. Inside the tube sits an insect with a potentially deadly bite, at least deadly to corn.

This African leafhopper (Cicadulina mbila) carries maize streak virus, a scourge endemic to sub-Saharan Africa that devastates fields. Kloppers, a plant pathologist and technical manager at Pannar Seeds in Greytown, South Africa, gathers a dozen more tubes from the insect house and clips them to additional plants. Tomorrow, after the bugs have eaten their fill, he'll remove the tubes and then wait.
The fruit of more than a dozen years of effort, these maize plants have been genetically altered to resist infection by the virus. In greenhouse studies so far, the plant is highly resistant. If it proves equally hardy in field trials scheduled to begin in late 2007, it would be a milestone: the first-ever genetically modified (GM) crop developed by Africans for Africa.

But Kloppers and the plant's inventors, microbiologist Jennifer Thomson, virologist Edward Rybicki, and collaborators at the University of Cape Town (UCT), have much larger goals in mind. In a region where chronic hunger is the norm, GM maize could help alleviate grain shortages and potentially even boost economic development, says Thomson. And because plans call for selling the seed to small-scale and subsistence farmers for minimal profit, the inventors also hope it will help burnish the dim reputation of GM technology.

None of that is assured, Thomson and Rybicki concede. The plant could still fail in the field, as other African GM crop varieties such as sweet potato and cassava have done. The failures not only have disappointed the technology's advocates, but they've also fanned the flames of anti-GM sentiment. Although South Africa is one of the few African countries to permit farmers to plant GM crops within its borders, naysayers there, who still have substantial clout, have condemned the technology as a mere moneymaking tool for Western companies. Moreover, they remain unconvinced that homegrown efforts such as UCT's maize will succeed. Another failure would give anti-GM groups even more ammunition. The stakes are high, and the UCT scientists are treading carefully.

The problem

Maize is not native to Africa. It likely sailed across the Atlantic from the New World as cargo during the early 1500s, according to historian James McCann of Boston University. Maize flourished and displaced other native crops during the 20th century because it grows in only a few months and requires relatively little labor--one pass of the plow instead of the three or four necessary for crops such as sorghum and millet. In sub-Saharan Africa, maize has become the staple food; it makes up more than 50% of calories in local diets. In Malawi alone, maize occupies 90% of cultivated land and accounts for 54% of Malawians' caloric intake.

Maize streak virus is likely homegrown, say scientists. It lives in native grasses. At some point, the virus adapted itself to maize and is now able to jump between grasses and corn through the bite of an infected leafhopper, which itself isn't sickened by the virus.

Like any other infection, the wrath of maize streak waxes and wanes with different environmental conditions. Some years, crop losses are minimal. But in bad years, such as 2006, it can wipe out from 5% to 100% of a farmer's maize crop.

For the past 25 years, African crop scientists have been trying to breed resistant maize by crossing plants that carry some degree of natural resistance. But the task has not been wholly successful. The trait is conferred by several genes on different chromosomes and isn't consistently transmitted to the next generation. "It's not quite clear how resistance genes are inherited," says Kloppers of Pannar Seeds. Moreover, traditionally bred varieties do not completely resist the virus, Kloppers explains. Many tolerate an infection but still produce stunted or deformed cobs.

A solution

In 1988, when Thomson took over as head of microbiology at UCT, GM technology seemed a perfect solution. Rybicki's plant virology group there was already intensively studying the virus. Perhaps they could engineer a way to stop it in its tracks?

The design seemed simple enough: The team studied the proteins necessary for the virus to replicate. If they inserted a mutated viral gene into the plant, which in turn expressed a mutated protein necessary for the virus to replicate at very high levels, it could beat out the virus's normal protein and immobilize the virus, they reasoned.

But getting the genes in proved tough, Thomson says. The UCT team first tried infecting maize with a widely used vector, Agrobacterium tumefaciens, carrying the genes, but to no avail. Ultimately, they successfully shot DNA into the plant using a gene gun. The GM maize plant carries a mutated form of a gene from the maize streak virus and two additional regulatory genes, one derived from maize itself and another from Agrobacterium.

Into the field

That was 6 years ago. Since then, the UCT scientists have been working closely with Kloppers at Pannar Seeds to test the plant's hardiness against infection. Kloppers has bred a previous version of the plant that carried an antibiotic-resistance gene through four generations. So far, it resists infection consistently. Moreover, the trait appears to be inherited in a dominant fashion.

Kloppers is repeating the experiment with a new group of plants that, because of environmental safety concerns, no longer carry an antibiotic-resistance gene. He expects to carry on crossing and checking inheritance and resistance through the next few months. Provided there are no major setbacks, he expects to apply for field trials during the latter part of this year.

Field trials are crucial to assess environmental and health risks, says Dionne Shepherd, a UCT postdoc who has been working on the project for the past 10 years. The scientists plan to examine whether the crop affects soil microorganisms and also whether it affects insects that feed on it. Other studies will also ensure that the added protein is indeed digestible and not an allergen.

If all goes well, the resistant maize will be the first GM crop to be field-tested in South Africa; to date, all GM crops planted in the country have been developed and tested elsewhere. The government is now developing its own expertise to evaluate environmental and human safety, says Shepherd, and because "UCT's maize is the most advanced locally produced GM product, they want to use our plant as a guinea pig," she adds.

To avoid the pitfalls that have beset other African GM crop varieties, the UCT scientists and Pannar have been working with regulators all along. At stake, they say, is not only their crop's fate, but also the technology's reputation.

A few years ago, Kenyan scientist Florence Wambugu, who was trained and supported by Monsanto, developed a sweet potato plant resistant to the feathery mottle virus. But when scientists field-tested the crop, traditionally bred resistant varieties outperformed it. Other efforts have also stumbled during field tests. Just a few months ago, scientists at the nonprofit Donald Danforth Plant Science Center in St. Louis, Missouri, announced that cassava plants genetically modified to resist cassava mosaic disease lost the trait after a few generations.

Both setbacks have fueled ongoing skepticism about GM technology. "All this talk about the technology's benefit for Africa is just a lot of PR hype to garner funding," says Mariam Mayet of the African Centre for Biosafety, an anti-GM lobby group in Richmond, South Africa. Most of the GM crops in the world are grown for animal feed or go toward food aid, Mayet says. "The benefit mainly goes to industrial agriculture, not to small-scale farmers."
Because UCT's maize is homegrown and was supported with very little corporate money--Pannar was the project's only corporate contributor--Thomson and Rybicki hope it can dodge some of these criticisms. Private foundations that typically give money with no strings attached and the South African government funded the project's bulk. To recoup its share of investment, Pannar expects the seed to cost no more than 15% higher than non-GM seed, says Kloppers. Small-scale or subsistence farmers would likely be charged much less, he adds.
If UCT's plant succeeds, it would be the first GM crop developed by a developing country. But Africans might not be the only beneficiaries. It might also become the poster child of what many argue is a useful and important technology--and for better or worse, one that desperately needs a public relations makeover.
Science, Jan. 12, 2007 Vol. 315. no. 5809, pp.182
© 2007 American Association for the Advancement of Science

SA accelerates development of cutting-edge biotech research

South African State research institutions and private-sector companies are forecast to spend R2,5-billion on biotechnology and genetic engineering research and development (R&D) over the next three years.

Of this, R500-million will be invested by the Department of Science and Technology (DST), R1,15-billion by other public-sector sources, and R855-million by private-sector industry.

“Biotechnology and genetics loom very large in the national science and technology policy,” affirms Science and Technology Minister Mosibudi Mangena.

“We (the State) have been able to invest R500-millionin biotechnology over the past three years and we have established the National Biotechnology Advisory Council (NBAC) to advise the Minister,” he cites.

Formally inaugurated on November 30 last year, the NBAC is a subcommittee of the National Advisory Council on Innovation.

Broadly, the NBAC’s terms of reference are to provide strategic advice to the Minister of Science and Technology, in particular with regard to ethical issues.

“We believe that biotechnology can make a big contribution to the country, to the economy,” he affirms.

“We’d like to see this R&D converted into products as soon as possible – for human, animal and plant health and yield,” he stresses.

One of the most exciting and cutting-edge fields in R&D, bio-technology and genetic engineering are also one of the oldest activities undertaken by humanity, dating back some 9000 years.

Quite simply, nearly everything people eat has been genetically modified – wheat, rye, barley and rice are all genetically-engineered forms of grass; pigs are genetically-modified boars; and so on – but, of course, what is new today is how such genetic modifications can be achieved: the means have changed, but not the objectives.

As expected, then, a number of the country’s science councils and other research institutions (including universities), and even some companies, have been involved in biotechnology for decades.

The most immediately obvious examples would be the Agricultural Research Council and the South African Institute for Medical Research.

But they are not the only ones – for example, the Council for Scientific and Industrial Research (CSIR) has also been involved in the sector for a long time and has a biosciences division.

Then there are the universities, with, for example, the School of Molecular and Cell Biology of the University of the Witwatersrand (Wits), the Institute for Infectious Diseases and Molecular Medicine (IIDMM) at the University of Cape Town (UCT), the Department of Biochemistry, Microbiology, and Biotechnology of Rhodes University, the African Centre for Gene Technologies (a joint network between the CSIR, Wits and the University of Pretoria), and other teams, units, or departments at the Universities of the North, Stellenbosch, Johannesburg, Limpopo, KwaZulu-Natal and the Western Cape.

In the private sector, the South African mining company, Gencor, undertook ten years of R&D, culminating in the construction of the world’s first bioleaching plant for gold-bearing sulphide concentrates in 1986 – the result was the technically and commercially viable BIOX process, now in use on at least three continents.

(In 1998 the gold assets of Gencor were merged with those of Gold Fields of South Africa to form new company Gold Fields Ltd; Gencor’s nonprecious metals assets were sold to Billiton in 1997 – Billiton subsequently merged with Australia’s BHP to form the current BHP Billiton in 2001.) BIOX was followed by the Bio-COP process for copper, developed in conjunction with Chile’s State-owned copper-mining giant, Codelco.

One of the key results of this legacy is that today South African minerals beneficiation, processing, and process control R&D institute Mintek is a leading centre of expertise in bioleaching technologies and R&D, globally, with more than 20 years’ experience.

Mintek, with technology partner BacTech, has developed the BACOX technology, which bioleaches more than 95% of the gold contained in refractory pyrite-arsenopyrite concentrates at gold mines in Australia and China.

Next in Mintek’s sights is the development of a cost-effective bioleaching technology for zinc, sulphide concentrates.

Mintek’s status in the area is evidenced by the fact that it is the coordinating institute for the bioleaching work package of the Biotechnology for Metal-bearing materials in Europe (BioMinE) project under the EU’s Sixth Framework Programme for R&D (which ended on December 31, 2006 – the Seventh Framework Programme has now started – however, BioMinE is set to run for another two years) The example of Mintek not only illustrates South Africa’s experience and success in developing profitable and highly useful biotechnologies, but also highlights the huge range of activities subsumed under the term ‘biotechnology’.

Bioleaching is, in fact, only one component of an area designated process biotechnologies.

Other process biotechnologies are fermentation, bioreactors,bioprocessing, biotransformation, biopulping, biobleaching, biodesulphurisation, bioremediation, biofiltration, phytoremediation, biological gas cleaning, bioaugmentation, bioindicators, process control, classical or traditional breeding, and extraction/purification/separation.

In turn, process biotechnologies represent only one of the major areas of biotechnology.

Another such area is, of course, genetics – this covers such research fields as genomics, bioinformatics, pharmacogenomics, gene probes/DNA markers, DNA sequencing/synthesis/amplification, recombinant DNA technologies, and transgenesis.

A third area is concerned with proteins and molecules, covering research fields like peptide/protein sequencing/synthesis, lipid/protein engineering, carbohydrate engineering, proteomics, enzymology, hormones and growth factors, call receptors/signalling/pheromones, antibodies, structural biology, and molecular modelling.

Then there is the area of cell and tissue culture and engineering,covering cell/tissue culture, tissue engineering, hybridisation, cellular fusion, vaccines/immune stimulants, and embyro manipulation.

A fifth area is subcellular organisms, covering fields such as viral vectors and gene therapy.

And then there is a wholeseries of research fields that do not fit neatly into overarching andunifying areas.

These include molecular high throughput screening, drug delivery, rational drug design, diagnostics, biochips, combinatorial chemistry, biomaterials, processing of blood products and substitutes, natural products chemistry, microbiology/virology/microbial ecology, biosensors, transgenics, and molecular synthesis.

Nor should one forget bionano-technology – this promises to be a highly innovative global science platform that examines the nexusbetween the manufactured nano-scale world and living systems.

This will have revolutionary applications like intelligent targeted drug delivery.

Biotechnology can also be looked at from the point of view of the depth of R&D a country can execute.

In this regard, the discipline can be divided into four categories.

First-generation biotechnology is simply the use of natural biological organisms to produce a product, such as using yeast to make beer.

Second-generation biotechnology involves the production of specific products, employing pure cell or tissue cultures from specifically selected organisms, through random cross-breeding or similar techniques, for their superior production or expression capabilities – without, however, introducing foreign DNA.

Third-generation biotechnology involves the introduction of selected foreign – that is, from across the species barrier – DNA, by means of recombinant DNA technology, thereby manipulating the genetic make-up of organisms, with the aim of making these genetically-modified organisms produce small molecules, compounds, or proteins.

The fourth category is biotechnology ‘support services’ – the ability to provide the activities essential to support biotechnology R&D, such as finance, equipment, the supply of essential inputs such as reagents, and appropriate legal frameworks and services.

Given all these elements, it is not surprising that South Africa, despite its established record of achievement and success in certain areas of the discipline, has spent the last few years strengthening and expanding its biotechnology capabilities.

A National Biotechnology Strategy was approved by the Cabinet in 2001, with the aim of stimulating the development of biotechnology skills, capacities and tools in the country.

“We have been able to establish regional biotechnology centres – the BRICs,” cites Mangena.

BRICs is the acronym for the Biotechnology Regional Innovation Centres, and together these form one of the implementing initiatives of the National Biotechnology Strategy.

(The NBAC is another such initiative.) Three BRICs have been established so far, namely eGoli BIO in Gauteng, Cape Biotech in the Western Cape, and ECoBio (which uses the trade name LIFElab) – this last centre covers the whole east coast region of the country (hence, the ECoBio acronym) from Nelspruit in the north, through Durban in the centre, to Port Elizabeth in the south.

In addition to the BRICs, a National Innovation Centre for plant biotechnology (designated PlantBio for short) was created in 2004.

A National Bioinformatics Network (NBN) has been created, made up of a series of nodes located in the various universities mentioned earlier; the objective is to develop capacity in bioinformatics and perform world-class bioinformatics research.

PlantBio and the NBN are also implementing initiatives for the National Strategy.

Because biotechnology can appear alarming to the uninformed, another key initiative in terms of the strategy is the Public Understanding of Biotechnology programme, to educate the public about the realities of the field and to stimulate informed discussion.

Then there is the Bio2Bizinitiative, which involves the holding of conferences and exhibitions with the aim of bridging the gap between the R&D institutions and centres, and business, in order to turn research results into commercial products, so stimulating national economic development.

At the end of last year, South Africa’s biotechnology capabilties received both a significant vote of confidence and a major boost from the international community with the announcement that the International Centre for Genetic Engineering and Biotechnology (ICGEB) had selected this country to host its third research laboratory.

Launched in 1983, with start of operations in 1987, the ICGEB is an intergovernmental organisation and a member of the United Nations system; it is headquartered in Trieste, Italy, which is also the location for one of its two existing research centres, the other being in New Delhi, India; it also has a network of affliated centres in many of its member countries.

The ICGEB exists to carry out innovative research in the life sciences for the benefit of developing countries; it strengthens the R&D capabilities of its members through training and funding programmes and advisory services.

It operates in the broad fields of biomedicine, biopharmaceuticals, biopesticide production, crop improvement, and environmental protection and remediation, and now has 71 member countries.

The ICGEB’s South African facility will be hosted by the IIDMM at UCT.

“This ICGEB decision indicates that South Africa is an important international player in biotechnology and genetics; it also shows that we have the capacity to take forward these capabilities,” highlights DST overseas bilateral co-operation GM Dr Chris Scheffer.

“It will also strengthen South African capacity and infrastructure,” he adds.

The ICGEB laboratory in Cape Town will be headed by a director, who will report to the director-general of the ICGEB; the director-general reports to the ICGEB board of governors and this board, with regard to scientific content, is assisted by a committee of scientific advisers, which is composed of 15 very distinguished scientists, drawn from both member and non-member countries, including three Nobel Prize laureates.

“Phase one of ICGEB Cape Town involves taking over existing labs at UCT, at both the Medical School and the Upper Campus, amounting to 710 m2 of lab space,” reports DST international cooperation and resources deputy director-general Dhesigen Naidoo.

The new facility is expected to become operational in June. “The five-year plan is to expand this to 4 000 m2 of lab space, either by taking over an existing building or, as in New Delhi, constructing a new and dedicated facility – it is still too early to decide which,” he reveals.

“This 4 000-m2 plan is a very realistic scenario; the current starting phase will involve five or six research groups, each with one principal researcher, two to three full-time researchers, plus post-graduate students; the 4 000-m2facility would accommodate 20 such groups, which would be quite incredible – this will give a huge boost to the implementation of our National Biotechnology Strategy,” he stresses.

“The ICGEB centres can have industrial partners, and these partners need not be private-sector – they can be pulic-sector institutions, like departments of health, and such institutions could manufacture products developed in the ICGEB labs and would only have to pay for the cost of development and production; private-sector partners would have to pay a licence fee to manufacture such products,” he points out.

“This attribute of the ICGEB is very attractive to us,” he explains.

ICGEB Cape Town will see a mixture of international and local scientists at work.

“We’re going to have, serving in South Africa, some of the crème de la crême of genetics and biotechnology researchers: this will impel the creation of a critical intellectual mass in the field in this country,” affirms Naidoo.

Copyright © Creamer Media (Pty) Ltd

Developing profitable partnerships in Quebec’s biotech and pharmaceutical industry

Montreal, Quebec – The environment in Quebec, which has the third highest number of biotechnology firms of any province or state in North America, is becoming increasingly competitive. As a result, collaborative agreements between pharmaceutical and biotech companies are getting more and more complex.

The Canadian Institute has developed its Forum on “Developing Successful Partnerships in Biotech and Pharma Industry” that will give you valuable insights on how to finance your company, deal with intellectual property issues, understand and apply success factors for finding and structuring strong partnerships.

During this unique event, you will get the valuable insight you need through:

- Practical sessions on how to finance your company, deal with intellectual property issues, negotiate and draft collaborative agreements, apply success factors for finding and structuring strong partnerships
- A panel of US and Canadian investors seeking investments opportunities in Canada

Conference Title: Developing Successful Partnerships in Biotech and Pharma Industry
Date: February 26 and 27, 2007
Location: Hotel Intercontinental – Montreal

Registrations are now being accepted at 1-877-927-7936, or online at www.CanadianInstitute.com.

PREMIER Biosoft International Releases TMA Foresight, a Statistical Tool for Tissue Microarray Data Analysis

Palo Alto, California - PREMIER Biosoft International on Janaury 15, 2007 announced the release of its new product, TMA Foresight. TMA Foresight is a statistical tool for tissue microarray data analysis designed especially for pathologists, clinicians and researchers.

TMA Foresight can be used for a wide variety of analysis of the tissue microarray data, ranging from simple descriptive statistics that include mean, sum, and variance to more advanced data correlation such as Hierarchical clustering and Kaplan Meier survival plots. You can explore the relatedness of prognostic marker expression and clinico-pathological variates with the outcome. Cox's Proportional Hazard analysis can be used for prognostic marker identification. Hierarchical clustering can be used to group patients on the basis of a clinico-pathological parameter or a biomarker. Kaplan-Meier plots and log-rank tests can then be used to identify prognostically significant clusters. You can threshold a particular marker and stratify patients into high risk and low risk cohorts.

TMA Foresight enables easy data pre-processing. It helps map the character data to numeric values with a click of a button. Moreover, the measurement level of each variable can be conveniently defined for use in different statistical analysis.

Says Kay Brown, V.P. Business Development and Marketing, "The tissue microarray market, is predicted to grow at 42% per year to over $163 million by 2008. We have designed TMA Foresight seeing the need for an easy-to-use specialized data analysis software tool."

Please visit the PREMIER Biosoft web site (www.premierbiosoft.com/tissue-microarray/index.html) to experience what TMA Foresight can do for you.

Consumers’ willingness to pay for biotech foods in China
By William Lin, Agapi Somwaru, Francis Tuan, Jikun Huang, and Junfei Bai

Based on a large-scale survey, this study employs the contingent valuation method to estimate consumers’ willingness to pay (WTP) for biotech foods in China and to account for the effects of respondents’ characteristics on the likelihood of purchasing biotech foods and WTP.

The survey, covering 1,100 consumers in 11 small-to-large cities (including Beijing and Shanghai) along China's eastern coast, was conducted in the fall of 2002.

Although the survey covers eight different kinds of biotech foods, soybean oil made from imported biotech soybeans and insect-resistant biotech rice are the focus.

A majority—about 60% or higher—of respondents were willing to purchase biotech foods without any price discounts. However, about 20% of them would only accept non-biotech foods.

Price premiums that respondents were willing to pay for non-biotech foods averaged about 23-53% for non-biotech soybean oil and 42-74% for non-biotech rice.

The lower bound WTP comes closer to the true value in light of hypothetical bias associated with the contingent valuation method.

The full article can be read at:
http://www.agbioforum.org/v9n3/v9n3a04-lin.htm


Achieving peaceful coexistence with biotechnology is a goal of University of California program

CALIFORNIA - Growing genetically engineered (GE) crops in the United States continues to stir debate, but some University of California scientists believe attention should now be focused on how farmers opposed to the technology and those in favor of it can step back from the controversy and successfully produce and market their crops in the way they personally see fit.

“A debate is being fueled by the perception that there has to be a choice between either organic agriculture or genetic engineering,” said Alison Van Eenennaam, a University of California Cooperative Extension (UCCE) specialist in animal genomics and biotechnology. “This ignores the possibility that different production systems can coexist alongside each other.”

Coexistence depends on establishing and implementing practical measures to ensure the integrity of crops destined for different markets. The first step, say some UC experts, is providing accurate information on the issue to farmers, environmentalists, lawmakers and consumers. UC’s biotechnology workgroup has crafted 13 fact sheets, reviewed by scientific experts for accuracy, outlining basic information about the production and safety of GE crops, foods, animal feed and animals.

The information will help counties and state agencies as they hammer out coexistence plans for organic farmers, farmers producing products for markets that reject GE crops, and farmers who consider GE crops necessary to compete in the global marketplace.

Interest in the use of GE in California agriculture began in earnest when Measure H, Mendocino County’s ordinance that banned the growth and propagation of GE plants and animals, was passed in March 2004. Subsequently, the Trinity County Board of Supervisors passed a similar measure imposing a ban within county borders and ballot initiatives like Mendocino’s were considered in Marin, San Luis Obispo, Butte and Humboldt counties. (Only the Marin initiative succeeded.) Groups opposed to the use of GE in California agriculture remain active in a number of California counties.

“The discourse regarding genetic engineering is often being inflamed by alarming assertions and facts that are not derived from, nor are they supported by, scientific research,” Van Eenennaam said. “There is a continued need to ensure that the public has access to science-based information and educational materials.”

According to a report released in December 2006 by the Pew Charitable Trust, 34 percent of Americans say they believe genetically modified foods are safe, 29 percent say they are unsafe and 37 percent had no opinion. According to a UC fact sheet, scientific evidence to date has indicated that foods developed using GE pose no greater risk to consumers than foods produced using traditional methods.

In the Pew study, consumers consistently underestimated their consumption of GE foods, with just 26 percent believing they have eaten such foods and 60 percent believing they have not. In fact, it is likely that all U.S. consumers have eaten foods containing some ingredients derived from GE crops.

“Seventy-five percent of processed foods contain genetically modified ingredients – things like cotton seed oil, soy protein, canola oil and high fructose corn syrup,” said UCCE biotechnology specialist Peggy Lemaux, author of two of the fact sheets.

A primary concern of growers producing food for GE-sensitive markets is the potential for some unintended presence of GE material in their product. A small amount of engineered genes in non-GE food can result from pollen flow or unintentional mingling during post-harvest storage, transportation or food processing. One hundred percent purity of any processed product, Lemaux said, is not achievable. Tolerance levels for unwanted material are applied in every crop sector, from certified seed to mainstream commodity production.

“The only way we can have coexistence is if both sides are willing to work together to ensure that they can successfully deliver products that meet their customers’ tolerance thresholds,” Lemaux said. “An achievable tolerance level for unwanted material in an end product is probably 1 percent or less. In Europe, products with 0.9 percent GE presence are marketed without labeling.”

San Luis Obispo County officials are currently developing a protocol for coexistence of GE and non-GE crops. The majority of voters there rejected Measure Q in 2004, which would have banned GE crops. But at the polls, nearly 50,000 individuals expressed their support for the ban.

At the request of the board of supervisors, San Luis Obispo County agricultural commissioner Bob Lilley assembled a committee to develop coexistence methods. UCCE horticulture advisor Mary Bianchi served as a member, supplying technical information from UC. Many questions raised by the committee are addressed in UC’s new series of fact sheets. The committee’s recommendations for coexistence were presented to the San Luis Obispo County Board of Supervisors last summer.

“One of the primary considerations is communicating where and when GE crops are grown to minimize GE presence in non-GE foods,” Bianchi said. “This has been done successfully for years by seed producers with mapping systems that identify where their certified seed fields are planted so that other seed producers can plan their planting strategies around the existing crops. We are exploring development of a similar notification process for county growers.”

Lemaux believes the efforts in San Luis Obispo County may serve as an example for other counties in California or regulators at the statewide level to implement policies that will allow for peaceful coexistence of those who favor GE crops and those who do not.

The free, downloadable fact sheets are:

Introduction to Genetic Modification by Lemaux
http://anrcatalog.ucdavis.edu/pdf/8178.pdf

Plant Genetic Engineering and Regulation in the United States by Alan McHughen, UC Riverside biotechnology specialist
http://anrcatalog.ucdavis.edu/pdf/8179.pdf

Safety of Genetically Engineered Foods by Carl Winter, UC Davis food toxicologist
http://anrcatalog.ucdavis.edu/pdf/8180.pdf

Genetic Engineering and Pollen Flow by Norman Ellstrand, UC Riverside geneticist
http://anrcatalog.ucdavis.edu/pdf/8182.pdf

Genetic Engineering and Animal Feed by Van Eenennaam
http://anrcatalog.ucdavis.edu/pdf/8183.pdf

Genetic Engineering and Animal Agriculture by Van Eenennaam
http://anrcatalog.ucdavis.edu/pdf/8184.pdf

Genetic Engineering and Fish by Van Eenennaam
http://anrcatalog.ucdavis.edu/pdf/8185.pdf

Plant Genetic Engineering and Intellectual Property Protection by Brian Wright, UC Berkeley agricultural economist
http://anrcatalog.ucdavis.edu/pdf/8186.pdf

Some Food and Environmental Safety Issues with GE Products: A Scientific Perspective by Lemaux
http://anrcatalog.ucdavis.edu/pdf/8187.pdf

Genetic Engineering and Organic Production Systems by Pamela Ronald, UC Davis plant pathologist, and Benny Fouche, UCCE San Joaquin County small farms advisor
http://anrcatalog.ucdavis.edu/pdf/8188.pdf

Methods to Enable Coexistence of Diverse Production Systems Involving Genetically Engineered Cotton by Robert Hutmacher, UC Davis agronomy specialist, Ron Vargas, UCCE Madera County emeritus field crops farm advisor, and Steven Wright, UCCE Tulare County field crops farm advisor
http://anrcatalog.ucdavis.edu/pdf/8191.pdf

Methods to Enable Coexistence of Diverse Corn Production Systems by Kent Brittan, UCCE Yolo County field crops farm advisor
http://anrcatalog.ucdavis.edu/pdf/8192.pdf

Methods to Enable Coexistence of Diverse Production Systems Involving Genetically Engineered Alfalfa by Dan Putnam, UC Davis agronomy specialist
http://anrcatalog.ucdavis.edu/pdf/8193.pdf
© 1992-2007 by SeedQuest

National Science Foundation provides $14 million to advance research in comparative genomics

Scientists will find improved ways of studying the structure, function and evolution of the genomes of economically important plants, thanks to $14 million in new awards from the National Science Foundation (NSF).

Resources to be developed include genomic sequences, genetic markers, maps and expressed sequence collections. These are much-needed tools for researchers working in areas as diverse as genome evolution and plant breeding.

Awardees will address scientific questions including the role of polyploidy in genome evolution, the genomic basis of speciation, and the relationships between cultivated plants and their weedy relatives.

"If the Plant Genome Research Program has been making the bricks that build a conceptual framework for the genomes of economically important crop plants, these projects will provide the mortar," said James Collins, NSF assistant director for biological sciences. "The impact of genomics in evolutionary, ecological and population studies of crop plants will be far-reaching."

Many crop plants have large, complex genomes that in some cases are "polyploid" - containing multiple genomes. Polyploidy is widespread in plants and animals, and can lead to dramatic changes in gene content and genome organization that are only just beginning to be understood.

A project led by researchers at Iowa State University will develop sequence and map resources to study polyploidy in cotton, while researchers at the University of Missouri will look at the impact of polyploidy on plant form in Brassica species, which includes plants such as canola and Brussels sprouts. Other projects at the University of Georgia and the University of Arizona will develop sequence resources to study genome organization in wheat and rice.

The outcomes from these projects will allow researchers to understand how extra copies of genes function in these plants, and how genomes from different sources can work together in a single plant.

The ever-growing collection of genome sequences is shedding light on the variation between individuals within a species. For example, in a forest of trees or a field of corn, there may be many versions of a particular gene, each with minor sequence differences. These sequence differences can sometimes have dramatic effects on growth and development.

Projects based at the University of California at Davis and Cornell University will catalog variants in pine trees and in maize, respectively, to allow researchers to link genetic variation with changes in gene function. This information could have applications in plant breeding.

More than half of the world's most cultivated crops have relatives that are invasive weeds, competing with the crop for nutrients and water and leading to reduced yields.

One example is red rice, a weedy form of rice that reduces the yields of cultivated rice by as much as 80 percent and contaminating harvests with its small red-coated grains. A project led by researchers at Washington University St. Louis will examine the regions of the red rice genome associated with weediness to find out whether it originated from the domesticated crop or if it was introduced as a weed from Asia.

A related project led by investigators at Michigan State University will investigate differences in gene expression in weedy and cultivated radishes to uncover which genes are associated with invasiveness.The outcomes of these projects could lead to a great understanding of how plants become weedy and invasive, and yield possible avenues for better selective control of weeds, scientists believe.

"The outcomes of this new program will tie together studies of the evolution of gene structure, function and regulation across the whole plant kingdom," said Collins.

About National Science Foundation

The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering, with an annual budget of $5.58 billion. NSF funds reach all 50 states through grants to nearly 1,700 universities and institutions. Each year, NSF receives about 40,000 competitive requests for funding, and makes nearly 10,000 new funding awards. The NSF also awards over $400 million in professional and service contracts yearly.
Copyright ©2007 by AAAS

Canada and India to collaborate on agriculture and biotechnology information exchange

OTTAWA, Ontario - Canada's New Government has announced the signing of a Memorandum of Understanding (MOU) with India to extend scientific collaboration in exchanging technology and expertise and in conducting research.

The agreement will provide opportunities for researchers and institutions to exchange information and expertise in agriculture, agri-food and rural development. Of particular interest to both countries are agricultural biotechnology, bio-pesticides and bio-fertilizers, functional and nutraceutical foods and environmental technologies.

On December 5, 2006, Canada's Deputy Minister of Agriculture and Agri-Food, Leonard J. Edwards, in New Delhi, on a trade mission to Sri Lanka and India, signed the MOU with Dr. Maharaj Kishan Bhan, Secretary, Department of Biotechnology of India's Ministry of Science and Technology.

Canada and India have a long history of cooperation in science and technology, including student exchanges. The signing of an MOU is a result of a series of scientific and technical exchanges between the two countries.

Late 2005, during a visit to Canada, India's Minister of Science and Technology signed the Bilateral Science and Technology Agreement between the two countries. The agreement targeted strategic areas for increased collaboration, including nanotechnology; information and communication technology; biotechnology, health research and medical devices; sustainable alternate energy and environmental technologies; and earth sciences and disaster management.

An Agriculture and Agri-Food Canada research team visited India in March 2006 to further explore opportunities for developing strategic alliances to enhance research collaboration between India and Canada. That delegation and a return visit to Canada in late spring by the Biotechnology Secretary of India's Ministry of Science and Technology helped to determine that both countries would benefit from cooperation in the areas of agriculture, agri-food and environmental sciences and technology.

The MOU does not involve an exchange of funding, but establishes guidelines for setting research priorities and projects. This new agreement builds on Canada's long history of cooperation in agricultural research with India, providing increased knowledge and expertise to both countries.
Copyright Agriculture and Agri-Food Canada

Biotechnology will help meet demand for food and fuel, BIO says

WASHINGTON - Biotechnology is helping American farmers continue to supply an economic, environmentally sustainable supply of food and raw material for biofuels, the Biotechnology Industry Organization (BIO) said January 8, 2007 in response to a recent Earth Policy Institute report.

BIO noted the EPI report underestimates the impact biotechnology will have in increasing yields of both corn and ethanol from corn as well as producing ethanol from cellulose, meeting worldwide demand for both food and fuel.

“Agricultural biotechnology is helping farmers increase corn yields so we can make more ethanol,” stated BIO President and CEO Jim Greenwood. “In addition, industrial biotech companies are developing new enzymes that make current ethanol processes more efficient and will soon allow the economical conversion of cellulosic crop residues to fuel. With ongoing advances in biotechnology, biofuels can help America meet nearly half its transportation-fuel needs by the middle of this century.”

BIO’s recently released report, “Achieving Sustainable Production of Agricultural Biomass for Biorefinery Feedstock,” outlines current and future feedstock supply challenges for the biofuel industry and discusses incentives to spur sustainable production, harvest and delivery of agricultural cellulosic biomass. The report shows that corn stover and cereal straw can supply 200 million dry tons of feedstock annually within three to five years, tripling current ethanol from corn production. The report is available http://www.bio.org/ind/biofuel/SustainableBiomassReport.pdf.

“The Earth Policy Institute’s calculations fail to take into account recent developments in the ethanol industry that will ramp up production of ethanol from cellulose,” said Brent Erickson, executive vice president of BIO’s Industrial and Environmental Section. “The technology for production of ethanol from cellulose is ready today. With industrial biotech processes ready for deployment and production -- by companies such as Abengoa, Iogen, Broin, Mascoma and others -- and currently available feedstock from agricultural residues such as corn stalks, ethanol production could reach three times current levels within three to five years as ethanol from cellulose is added to the current biofuel technology mix.”

BIO represents more than 1,100 biotechnology companies, academic institutions, state biotechnology centers and related organizations across the United States and 31 other nations. BIO members are involved in the research and development of healthcare, agricultural, industrial and environmental biotechnology products.
© Business Wire 2007

Food biotechnology: A study of U.S. consumer attitudinal trends, 2006 report

After a decade of consumer attitudinal research, it is clear that a majority of consumers are confident in the safety of the U.S. food supply and express little to no concern about food and agricultural biotechnology. A significant majority also have no outstanding concern about labeling foods produced using biotechnology as such.

Higher awareness correlates with purchase intent, with a few exceptions, and the provision of information and context has a positive effect on attitudes. Therefore, with increasing numbers of consumers who state that they have heard nothing about biotechnology, there is a clear need for science-based information about the subject. This information should be conveyed clearly and accurately to the public, using understandable language and providing contextual information.

Methodology

The International Food Information Council (IFIC) commissioned Cogent Research to conduct the 11th in a series (1997 to 2006) of quantitative assessments of U.S. adult consumer attitudes toward food biotechnology during June and July of 2006. The purpose of the study is to:


track public awareness and perceptions of food biotechnology;

identify concerns related to foods that have been produced using biotechnology, within the context of broader food safety and labeling issues;

measure the extent to which consumers change their behavior because of biotech foods; and

measure the extent to which certain benefits of agricultural biotechnology resonate with the public.

In 2006, the IFIC consumer survey on food biotechnology migrated from phone to Web methodology. Collection of consumer data via the Internet is currently considered the preferred survey methodology, due to improved access to consumers and potentially a more accurate measure of consumer opinion, compared to phone data collection.

The migration to Web from phone included measures to ensure the continued ability to track attitudes over time, and to correct for observed differences that were due to changes in methodology. The sampling error is = 4.4%, and statistically significant differences are represented at the 95% confidence level. Finally, the data were weighted according to U.S. Census data, in order to be nationally projectable.

Findings

Overall, a majority of Americans are confident in the safety of the U.S. food supply and express little to no concern about food and agricultural biotechnology.

Nearly three-fourths (72%) of consumers say they are confident in the safety of the U.S. food supply. When prompted to indicate food safety concerns, most consumers mention microbial foodborne illness (36%) or improper handling (35%), while only three percent of all consumers cite food biotechnology.

And although more than half of all Americans report avoiding some type of food or food ingredient (59%), none mention biotech foods as something they are avoiding. When asked directly, only two percent say they have recently changed their behavior due to concerns about food biotechnology.

Many consumers are neutral (33%) or unsure (18%) when asked specifically for their opinion on food biotechnology. However, those consumers who do have an opinion are almost twice as likely to have a positive view (32%) than to have a negative view (17%).

Food biotechnology is not a consumer labeling demand.

An overwhelming majority of consumers (82%) state that there is no information that they would like to see added to food labels. Only one percent name biotechnology as information they would like to see added. These findings have been consistent since 2001 when the question was first asked on the survey. Additionally, support for the U.S. Food and Drug Administration’s (FDA) current policy regarding labeling of foods produced through biotechnology is strong at sixty-four percent, with another one-fourth (24%) holding neutral views, and only twelve percent opposing the current policy.

Although many consumers have heard at least “a little” about food biotechnology, awareness has declined and knowledge is superficial.

Although close to three-fourths (71%) of consumers have heard at least “a little” about biotechnology, only eight percent have heard “a lot”. Three-fourths (74%) of consumers are unaware that biotech foods are currently available in the supermarket, and the twenty-six percent who are aware most often name “vegetables” as the food that is available.

In light of the lack of high awareness of food biotechnology, it is not surprising that over half (53%) of consumers are unsure about potential benefits. However, consumers with an opinion are twice as likely to believe biotechnology will provide benefits in the next few years than not (33% vs. 14%, respectively). Those who believe there will be benefits are most likely to cite improved nutrition (41%) or quality (35%).

Communicating specific benefits may enhance perception.

Learning of the benefits of biotech foods has a significant impact on consumers’ likelihood to buy, particularly for a health benefit (77% likely to buy for increased omega-3 fatty acid content; 75% for reduced saturated fat content) or insect protection/pesticide reduction (75%), but also for improved taste or freshness (63%).

In general, likelihood to purchase biotech foods increases as awareness increases. However, awareness levels have less impact on purchase intent when it comes to consuming healthful fats, where purchase intent is high across all awareness levels.

Although awareness is low, consumers remain open to the broad concept of animal biotechnology, in general.

Animal biotechnology favorability has shifted toward both more positive impressions (“very favorable” has increased from 1% to 6%) while the most negative impressions have declined (12%, down from 16%). Still, there are more who don’t know enough to form an opinion (30%, up from 24%), and twenty-eight percent are neutral.

At the same time, the number of consumers who have read or heard "nothing at all" about animal biotechnology has increased for the second year in a row (55% vs. 46% in 2005 and 40% in 2004). Indeed, those who don’t know enough to form an opinion are more likely to have heard nothing at all about the technology.

There is evidence of the positive impact that information can have on acceptance of animal biotechnology, in some cases. Information examined in this study included descriptions of specific types of animal biotechnology, benefits, and government conclusions regarding safety. When specific types of animal biotechnology are described, consumers express higher favorability for animal genomics (37%) and genetic engineering (35%), compared to favorability for the broad concept of animal biotechnology. (See discussion of animal cloning below.)

Regarding the impact of benefits information, more than half of consumers say that their impression of animal biotechnology improves when they are told it can improve the quality and safety of food (59%). Nearly half are positively impacted by information regarding increases in farm efficiency (47%), and reduction of environmental impact of animal waste (49%). In addition, more than half (58%) of consumers say they would be likely to buy products from animals enhanced through genetic engineering if the FDA determined they were safe.

Consumers remain opposed to the notion of animal cloning, as well as the use of cloned animals for breeding.

Less than one-fifth (16%) of U.S. adults give a favorable rating for their impression of animal cloning, while over half (56%) give an unfavorable rating. Regarding the use of cloned animals for breeding purposes, more consumers are neutral (36%) compared to those who are neutral toward cloning (28%), and fewer are unfavorable (46%).

Fewer consumers state that they are “not at all likely” to purchase foods from cloned animals (30% vs. 35%), compared to 2005, as well as an increase in those who are “very likely” to purchase foods derived from the offspring of cloned animals (9% vs. 4%), with safety assurances from FDA. However, the majority remain unlikely to purchase foods from cloned animals (58%) or their offspring (59%).

The majority of consumers continue to be unaware of plant-made pharmaceuticals, but those who are aware tend to be favorable.

The majority (59%) of consumers say they know "nothing at all" about using biotechnology to produce medicine in food crops. Although twenty-five percent of consumers say they don’t know enough about plant-made pharmaceuticals to form an opinion and twenty-seven percent are neutral, those who have formed an opinion lean heavily towards the positive (42% favorable versus 6% unfavorable).

Conclusions

While there is no overwhelming consumer demand for more information about food biotechnology, it will be important to continue to make science-based information available to the public. Should interest in foods enhanced through biotechnology increase, or questions arise, health professionals, government officials, and food providers should be prepared to help the public understand issues such as safety, regulation, and benefits of the technology. Such efforts can contribute to an overall appreciation for how the foods consumers enjoy make the journey from farm to plate.

A complete copy of the report can be downloaded from IFIC at the following address: http://www.ific.org/research/upload/2006%20Biotech%20Consumer%20Research%20Report.pdf

Copyright © International Food Information Council

Indian biotech has finally arrived on the global scene
By Kiran Mazumdar-Shaw

The year 2006 will go down as a landmark year for Indian biotechnology. Ernst & Young ranked India third in the region based on the number of biotech companies after Japan and Korea.

The year saw a number of key developments. Indian mega corporate Reliance Industries invested in excess of $100 million in building both manufacturing and clinical development capabilities in Reliance Life Sciences and ended the year by acquiring a 74% stake in a UK biotech company GenMedix. Earlier, Nicholas Piramal acquired another UK-based biotech company, Avecia to strengthen its innovation and contract research base.

In November, Advinus, a Tata-backed life sciences company, announced a $150 million drug discovery deal with Merck. In mid-September, Indian biotech major, Biocon, launched its anti-EGFR monoclonal antibody BIOMAb-EGFR, heralding the first proprietary, biotech drug with a ‘Made in India’ label. Another landmark investment deal saw French Biotech major Merieux Alliancve pick up a 60% controlling stake in Shantha Biotechnics, catapulting Shantha’s vaccine capabilities onto the world stage.

Pune-based Serum Institute continued to dominate vaccine production in the country and announced plans for an IPO in 2007. The prospects for research services continued to show excellent promise with Syngene, GVK Bio and Jubilant Biosys registering exponential growth.

Whilst the investor community remained skeptical of the Indian biotech sector, Avesthagen successfully attracted a 20 million euro investment from a leading European fund. On the regulatory and policy front, the biotech sector witnessed the implementation of a new regulatory regime proposed by the Mashelkar Committee for recombinant drugs and the MS Swaminathan Committee for GM crops.

The department of biotechnology rolled out the strategy document for the sector that included the launch of the SBIRI (Small Business Innovation Research Initiative) scheme to assist start up enterprises in the incubation phase. The agri-biotech sector saw a significant increase in acreage for Bt cotton whilst the volatility in oil prices raised the profile of bio-fuels with companies like Praaj Industries and enzyme producers Novozymes and Biocon being the main beneficiaries.

The prime impetus for growth of the Indian biotech sector emanates from our large reservoir of scientific talent pool, a wide network of research laboratories, a vibrant pharma industry and fast-growing clinical capabilities.

India’s ecological and population diversity is an advantage from a research and discovery standpoint. Bioinformatics and Bio-IT have a key role to play in personalised medicine both with respect to diagnostics and therapies. Biometrics is another emerging opportunity where India's computational software skills and proven cost competitiveness can be strong levers. Stem cells and regenerative medicine have been identified as areas of strategic importance with enabling policies backing it where companies like Reliance Life Sciences have taken the lead.

Another important area for India is biogenerics or biosimilars as a number of biological drugs are slated to go off patent in the coming years. India's competitive edge derives from strong bio-manufacturing skills coupled with a regulatory framework in place for approving generic versions of biologicals like Insulin, GCSF, Hep B vaccine, Streptokinase etc.

The recent guidelines released for select biosimilars by EMEA and the likelihood of USFDA doing the same will see several Indian companies positioning themselves to be global players in this segment.

The Indian biotech sector has certainly gathered momentum over the last two decades and has finally arrived on the global scene. The sector has crossed many hurdles in reaching this point. The challenges ahead are enormous in terms of building specialised human capital, creating internationally benchmarked regulatory and IP infrastructure and the timely implementation of the National Biotechnology Strategy.

The ultimate hallmark of success will lie in India bringing to world markets novel and proprietary biotech products. This will largely depend on bridging the existing gaps that exist in discovery and pre-clinical development. Perhaps the largest gap that needs to be bridged is one that involves the innovation interface between academia and industry. Without this, there is a danger of knowledge being restricted and not shared which will be detrimental to the innovation-led mindset in the country.

There are promising signs on the horizon: skeptical investors are slowly but surely beginning to value the biotech sector more confidently. This has catalysed a number of trans-national alliances as well as M&A activity. The presence of large Indian conglomerates has introduced an air of seriousness to the sector. The ministry of science and technology along with DBT are ascribing large budgetary allocations for biotechnology. 2007 augers well for Indian biotechnology and I am confident that we will see some globally significant happenings in the near future that will catapult India into a dominant leadership position.
© 2006: Indian Express Newspapers (Mumbai) Ltd

GM food is answer to poverty and hunger
By Rob Edwards

People are being urged by Scotland's new chief scientific adviser to embrace genetically modified (GM) food as an answer to poverty, hunger and toxic pollution.

Professor Anne Glover, herself a genetic engineer, is urging consumers to ignore labels like "Frankenstein foods" because they are misleading and damaging. The potential benefits of GM crops are "huge", she says, and the risks "extremely small".

But her enthusiasm for GM food has infuriated environmentalists, who fear she could exert an important influence on Scottish ministers. They argue GM crops are "potentially dangerous" and point out that they have been widely rejected by the public and supermarkets.

Glover, a molecular biologist from the University of Aberdeen, was appointed chief scientific adviser earlier this year by Nicol Stephen, the deputy first minister. She is an expert on microbes and has genetically engineered bacteria to glow in the dark.

She has taken luminescence genes from deep sea organisms and transplanted them into soil bacteria. The healthier the soil, the brighter the bacteria glow, making it possible to use them as biological sensors for measuring environmental contamination.

It's that research which informs Glover's view of GM foods. "I'm absolutely in favour of genetic manipulation carried out under appropriate guidelines," she told the Sunday Herald. GM food could help end poverty and hunger in the world, as well as reducing farmers' use of hazardous pesticides, she said. "I think GM crops might well be able to help us in addressing some of these issues."

Crops could be engineered to resist drought, or to have a higher nutritional value, she argued. They could also be developed to produce biofuels to use as a renewable fuel for vehicles.

Blight-resistant GM potatoes being trialed in England could help Scotland's potato market, she suggested. GM crops could also deliver cheaper foods with longer shelf lives.

"They have a significant amount to offer, globally, in terms of how they could be used to better produce crops under difficult conditions and to reduce the amount of chemicals used in agriculture," Glover said.

The public debates that had so far taken place had been "really poorly informed", she added. "There's an astonishing lack of knowledge about genetic modification."

Glover also said that she didn't understand why people were prepared to eat fast food that was high in fat and preservatives known to be bad for health, but were worried about GM.

Glover was particularly concerned about the widespread use of the term "Frankenstein foods" to describe GM products. "That's really unhelpful," she said. "We need to learn from what's happened over GM foods to ensure that we don't allow developing new technologies to be hijacked by phrases which are all to do with headline-grabbing and nothing to do with reality."

But her views were fiercely rejected by the Soil Association, which promotes and certifies organic food. "There is no evidence whatever that Scottish consumers want GM products in their food supplies," said Hugh Raven, the association's director in Scotland.

"If the Scottish Executive's advisers can't grasp that in a democracy it's not very clever to foist potentially dangerous new technologies onto reluctant consumers, God help us all."

Raven pointed out that several studies had raised questions about the safety of GM organisms for human consumption. Some showed that modified genes could transfer into bacteria in the human gut.

Scottish ministers have postponed a long-promised consultation on the "coexistence" arrangements under which GM crops might be grown north of the Border until next summer. No GM crops have been grown in Scotland since trials of GM oil seed rape ended in 2003.

The Scottish Greens' environment speaker, Mark Ruskell MSP, has proposed a bill to Holyrood to make GM companies strictly liable for any economic damage caused by contamination from GM crop trials and commercialisation.

"I think the professor needs to wake up to the reality of GM crops and to the basics of plant biology. Once the GM genie is out the bottle, there is no going back," Ruskell said.

"She only needs to look to Canada where farming businesses have been left crippled after their crops have become contaminated. Given that GM crops would ruin the Scottish agriculture industry, I'm at a loss as to why the government's chief scientific adviser is determined to push this agenda."

Glover, however, stressed that scientists should not impose GM onto an unwilling public. They should explain the benefits, leaving it up to people and politicians to decided what they wanted.

©2006 newsquest (sunday herald) limited

FDA set to OK food from cloned animals
By Libby Quaid

The US government has decided that food from cloned animals is safe to eat and does not require special labeling.

The Food and Drug Administration planned to brief industry groups in advance of an announcement Thursday morning. The FDA indicated it would approve cloned livestock in a scientific journal article published online earlier this month.

Consumer groups say labels are a must, because surveys have shown people to be uncomfortable with the idea of cloned livestock.

However, FDA concluded that cloned animals are "virtually indistinguishable" from conventional livestock and that no identification is needed to judge their safety for the food supply.

"Meat and milk from clones and their progeny is as safe to eat as corresponding products derived from animals produced using contemporary agricultural practices," FDA scientists Larisa Rudenko and John C. Matheson wrote in the Jan. 1 issue of Theriogenology.

Labels should only be used if the health characteristics of a food are significantly altered by how it is produced, said Barb Glenn of the Biotechnology Industry Organization.

"The bottom line is, we don't want to misinform consumers with some sort of implied message of difference," Glenn said. "There is no difference. These foods are as safe as foods from animals that are raised conventionally."

Critics of cloning say the verdict is still out on the safety of food from cloned animals.

"Consumers are going to be having a product that has potential safety issues and has a whole load of ethical issues tied to it, without any labeling," said Joseph Mendelson, legal director of the Center for Food Safety.

Carol Tucker Foreman, director of food policy at the Consumer Federation of America, said the FDA is ignoring research that shows cloning results in more deaths and deformed animals than other reproductive technologies.

The consumer federation will ask food companies and supermarkets to refuse to sell food from clones, she said.

"Meat and milk from cloned animals have no benefit for consumers, and consumers don't want them in their foods," Foreman said.

The FDA scientists wrote that by the time clones reached 6 to 18 months of age, they were virtually indistinguishable from conventionally bred animals.

Final approval of cloned animals for food is months away; the FDA will accept comments from the public after issuing a draft risk assessment on Thursday.

Those in favor of the technology say it would be used primarily for breeding and not for steak or pork tenderloin.

Cloning lets farmers and ranchers make copies of exceptional animals, such as pigs that fatten rapidly or cows that are superior milk producers.

"It's not a genetically engineered animal; no genes have been changed or moved or deleted," Glenn said. "It's simply a genetic twin that we can then use for future matings to improve the overall health and well-being of the herd."

Thus, consumers would mostly get food from their offspring and not the clones themselves, Glenn said.

Still, some clones would eventually end up in the food supply. As with conventional livestock, a cloned bull or cow that outlived its usefulness would probably wind up at a hamburger plant, and a cloned dairy cow would be milked during her breeding years.

That's unlikely to happen soon, because FDA officials have asked farmers and cloning companies since 2001 to voluntarily keep clones and their offspring out of the food supply. The informal ban would remain in place for several months while FDA accepts comments from the public.

Approval of cloned livestock has taken five years because of pressure from big food companies nervous that consumers might reject milk and meat from cloned animals.

To produce a clone, the nucleus of a donor egg is removed and replaced with the DNA of a cow, pig or other animal. A tiny electric shock coaxes the egg to grow into a copy of the original animal. Cloning companies say it's just another reproductive technology, such as artificial insemination, yet there can be differences between the two because of chance and environmental influences.

Some surveys have shown people to be uncomfortable with food from cloned animals; 64 percent said they were uncomfortable in a September poll by the Pew Initiative on Food and Biotechnology, a nonpartisan research group.
Copyright 2006 Associated Press

Scientists get OK for engineered peanuts urg "due diligence"
By Elliott Minor

A leading industry group has given scientists the go-ahead to build genetically engineered peanuts that could be safer, more nutritious and easier to grow than their conventional version.

The work could lead to peanuts that yield more oil for biofuel production, need less rainfall and grow more efficiently, with built-in herbicide and pest resistance - traits that have already been engineered into major crops such as cotton, corn, soybeans and canola.

For consumers, the work could lead to peanuts with enhanced flavor, more vitamins and nutrients, and possibly even nuts that are less likely to trigger allergic reactions, a life-threatening problem for a small percentage of the population and a major food industry concern.

A few researchers have been genetically modifying peanuts for at least a decade, but their discoveries have had little impact because the industry, fearing a consumer backlash, was reluctant to support the work.

However, with the two leading peanut-producing countries, China and India, working aggressively on transgenic peanuts, the American Peanut Council and its research arm, the Peanut Foundation, this month approved a major policy change. The council represents all segments of the industry - growers, shellers, exporters and manufacturers.

The foundation urged scientists to move ahead with "due diligence" on genetically engineered peanuts.

The work is expected to cost about $9.5 million and will require university, government and industry support.

"It's a significant redirection in their thinking," said Peggy Ozias-Akins, a University of Georgia horticulture professor who has been working with genetically modified peanuts since the late 1990s.

The foundation also called for additional genome studies to learn more about the location and function of the natural peanut genes.

Because peanuts are considered a minor crop, their genetics still have not been studied as extensively as major crops such as soybeans, Ozias-Akins said.

Peanuts are believed to have originated in South America at least 3,500 years ago. Farmers in the Southern U.S. only started cultivating them in the early 1900s when the boll-weevil made it nearly impossible to grow cotton. Now they are grown in 15 states from Virginia to New Mexico. Georgia is traditionally the nation's No. 1 producer.

The U.S. peanut acreage dropped from nearly 1.7 million acres in 2005 to 1.2 million this year, while the acreage for two crops that benefit from genetic modification, cotton and soybeans, increased.

While experts say peanut acreage may drop again next year, scientists believe genetically modified peanuts could help reverse the trend.

A group of 14 university, U.S. Department of Agriculture and food industry scientists, including Ozias-Akins, prepared a report on biotech peanuts and presented it recently to the Peanut Foundation. The scientists concluded the technology could reduce growing costs, improve nutrition and overall quality for consumers and have the potential to reduce the allergy threat in peanuts.

"There is a sense in the industry that genetically modified products are becoming slightly more accepted in most of the world and that by the time we would have the first genetically modified peanut on the market - five years - that trend will have accelerated," said Howard Valentine, the Peanut Foundation's executive director.

A small amount of genetically modified sweet corn, squash and about half of Hawaii's papayas are the only U.S. crops currently grown for human consumption, said Gregory Jaffe, biotechnology director for the Center for Science in the Public Interest, a food and nutrition consumer advocacy group.

"Overall, our view is that genetic engineering is a technique that can be used to overcome grower problems, or to enhance consumer value in products," he said. "We support that as long as those products have been determined safe for human consumption."
Copyright 2006 Associated Press

German industry collaborating closely on microbial genome research

DUSSELDORF - Prominent companies in the chemicals, pharmaceuticals and nutrition industries have come together mid December 2006 for the first time under the umbrella of the “Industrieverbund Mikrobielle Genomforschung” (industry/science association to promote microbial genome research), Dusseldorf, with the aim of advancing microbial genome research as a technology with broad industrial application.

The work is being carried out in close cooperation with the Federal Ministry of Education and Research (BMBF) and academic research groups. An international body of experts has already delivered a very positive assessment of the first projects, which have a total volume of 42 million euros over five years and are each financed equally by the BMBF and industry. Over the next few years the projects will seek to improve how efficiently micro-organisms are used in technical processes and to develop new products from micro-organisms with new properties.

This work will make a substantial contribution to the further development of white biotechnology in Germany, a country that is assuming a pioneering role in this technology both in academic research and in industrial application. Industry and the BMBF will provide around 600 million euros for white biotechnology projects over the next ten years.

The Industrieverbund Mikrobielle Genomforschung is supported by BASF, Bayer Crop Science, BRAIN, Degussa, Henkel, Milupa, Schering, Südzucker and Wacker, as well as other small and medium-sized companies. Dr. Karl-Heinz Maurer, Chairman of the Industrieverbund Mikrobielle Genomforschung, comments: “The use of genome information to optimize micro-organisms and their products is becoming a key factor in the global race to be first with the best products and processes in white biotechnology.”

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